What is TA-65
Made from a Chinese herb called Astragalus membranaceus, the “nutraceutical” is referred to by the equally futuristic and drab-sounding name of TA-65. And it claims to reverse the clock at a cellular level, all the way down to our DNA. The pill purports to restore our telomeres—the protective caps at the end of our DNA. Like the plastic tips at the end of shoelaces, these caps, with time, illness, and stress, eventually wear down, leading to physical signs of aging. Scientists now view telomere length as an overall marker of biological aging.
Telomeres are structures at the ends of chromosomes that shorten during cell division and eventually signal an irreversible state of growth arrest known as cellular senescence. To delay this cellular aging, human T cells, which are critical in the immune control over infections and cancer, activate the enzyme telomerase, which binds and extends the telomeres. Several different extracts from the Astragalus membranaceus root have been documented to activate telomerase activity in human T cells. The objective of this research was to compare two extracts from Astragalus membranaceus, TA-65 and HTA, for their effects on both telomerase and proliferative activity of human CD4 and CD8 T cells. Our results demonstrate that, TA-65 increased telomerase activity significantly (1.3 to 3.3-fold relative to controls) in T cell cultures from six donors tested, whereas HTA only increased telomerase levels in two out of six donors. We also demonstrate that TA-65 activates telomerase by a MAPK- specific pathway. Finally, we determine that during a three-day culture period, only the T cells treated with the TA-65 extract showed a statistically significant increase in proliferative activity. Our results underscore the importance of comparing multiple telomerase activators within the same experiment, and of including functional assays in addition to measuring telomerase activity.
Read more at http://www.mdpi.com/2073-4409/2/1/57